Mitochondria as target of Quantum dots toxicity

► The present work investigated the toxicity of CdTe QDs on the function of mitochondria isolated from rat livers. ► These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level. ► QDs toxicity on mitochondria indicates that the QDs require to be further improved bef...

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Veröffentlicht in:Journal of hazardous materials 2011-10, Vol.194, p.440-444
Hauptverfasser: Li, Jiahan, Zhang, Yue, Xiao, Qi, Tian, Fangfang, Liu, Xiaorong, Li, Ran, Zhao, Guangyuan, Jiang, Fenglei, Liu, Yi
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Sprache:eng
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Zusammenfassung:► The present work investigated the toxicity of CdTe QDs on the function of mitochondria isolated from rat livers. ► These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level. ► QDs toxicity on mitochondria indicates that the QDs require to be further improved before they can be safely used in clinic. Quantum dots (QDs) hold great promise in many biological applications, with the persistence of safety concerns about the environment and human health. The present work investigated the potential toxicity of CdTe QDs on the function of mitochondria isolated from rat livers by examining mitochondrial respiration, swelling, and lipid peroxidation. We observed that QDs can significantly affect the mitochondrial membrane properties, bioenergetics and induce mitochondrial permeability transition (MPT). These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level.
ISSN:0304-3894
1873-3336
DOI:10.1016/j.jhazmat.2011.07.113