Molecular Characterization of Factor V Leiden G1691A and Prothrombin G20210A Mutations in Saudi Newborns with Stroke

This study examined a possible association between the mutations related to Factor V Leiden and Factor II (prothrombin) and stroke in Saudi neonates. A multiplex PCR was established to detect Factor V Leiden G1691A and prothrombin G20210A mutations in 72 neonatal stroke subjects and 70 healthy adult...

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Veröffentlicht in:	Biochemical genetics 2011-10, Vol.49 (9-10), p.601-610
1. Verfasser:	Gawish, Gihan E-H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Blood Coagulation Disorders - congenital Blood Coagulation Disorders - genetics Cerebral Palsy - congenital Cerebral Palsy - genetics Factor V - genetics Gene Frequency Genetic Association Studies Genetics Genotype Genotypes Human Genetics Humans Infant, Newborn Intracranial Hemorrhages - congenital Intracranial Hemorrhages - genetics Intracranial Thrombosis - congenital Intracranial Thrombosis - genetics Medical Microbiology Mutation Neonates Polymorphism, Single Nucleotide Prothrombin - genetics Risk factors Saudi Arabia Sequence Analysis, DNA Stroke - congenital Stroke - genetics Zoology
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Zusammenfassung:	This study examined a possible association between the mutations related to Factor V Leiden and Factor II (prothrombin) and stroke in Saudi neonates. A multiplex PCR was established to detect Factor V Leiden G1691A and prothrombin G20210A mutations in 72 neonatal stroke subjects and 70 healthy adult controls with no family history of thromboembolic diseases. The frequency of the homozygous normal genotype (GG) of both genes was found to be significantly lower in the stroke subjects than in the controls ( P
ISSN:	0006-2928 1573-4927
DOI:	10.1007/s10528-011-9435-7