Inactivated and adjuvanted whole-virion clade 2.3.4 H5N1 pre-pandemic influenza vaccine possesses broad protective efficacy against infection by heterologous clades of highly pathogenic H5N1 avian influenza virus in mice

Highlights ► Alum-adjuvanted H5N1 rgAnhui (clade 2.3.4) vaccine induced broad cross-reactive neutralizing antibodies. ► The rgAnhui vaccine elicited protective immunity in mice against challenge infections with heterologous clade H5N1 viruses. ► Vaccine formulation with alum adjuvant allowed sparing...

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Veröffentlicht in:	Vaccine 2011-10, Vol.29 (46), p.8330-8337
Hauptverfasser:	Harada, Yuichi, Ninomiya-Mori, Ai, Takahashi, Yoshimasa, Shirakura, Masayuki, Kishida, Noriko, Kageyama, Tsutomu, Tada, Yoshikazu, Tashiro, Masato, Odagiri, Takato
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvanted H5N1 whole virion pre-pandemic influenza vaccine Adjuvants Adjuvants, Immunologic - administration & dosage Allergy and Immunology aluminum Aluminum hydroxide Aluminum Hydroxide - administration & dosage Animals antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigenic variants antigens Applied microbiology Avian influenza virus Biological and medical sciences blood serum Body Weight Combined vaccines Cross Protection Cross Reactions Cross-neutralizing antibodies Cross-protective immunity Data processing Epidemiology Female Fowl plague Fundamental and applied biological sciences. Psychology H5N1 avian influenza immune response Immunity Immunogenicity Immunoglobulin G Immunoglobulin G - blood Infection influenza Influenza A virus Influenza A Virus, H5N1 Subtype - classification Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - immunology Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Mice Mice, Inbred BALB C Microbiology Miscellaneous Mortality neutralization tests Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - prevention & control Pandemics Poultry Proteins Studies Survival Survival Analysis survival rate Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Viral infections Virology virulence Viruses weight loss
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Zusammenfassung:	Highlights ► Alum-adjuvanted H5N1 rgAnhui (clade 2.3.4) vaccine induced broad cross-reactive neutralizing antibodies. ► The rgAnhui vaccine elicited protective immunity in mice against challenge infections with heterologous clade H5N1 viruses. ► Vaccine formulation with alum adjuvant allowed sparing vaccine antigen.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.08.091