Effect of butylated hydroxytoluene (E321) pretreatment versus l -arginine on liver injury after sub-lethal dose of endotoxin administration
Highlights ► Butylated hydroxytoluene (BHT or E321) is a widely used food antioxidant. ► It may accumulate in liver due to continual intake of BHT-protected foods. ► Consumption of enteric bacteria-contaminated foods may cause serious endotoxemia. ► In case of BHT accumulation, endotoxemia reduces l...
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| Veröffentlicht in: | Environmental toxicology and pharmacology 2011-11, Vol.32 (3), p.457-464 |
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| container_title | Environmental toxicology and pharmacology |
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| creator | Engin, Ayse Basak Bukan, Neslihan Kurukahvecioglu, Osman Memis, Leyla Engin, Atilla |
| description | Highlights ► Butylated hydroxytoluene (BHT or E321) is a widely used food antioxidant. ► It may accumulate in liver due to continual intake of BHT-protected foods. ► Consumption of enteric bacteria-contaminated foods may cause serious endotoxemia. ► In case of BHT accumulation, endotoxemia reduces liver antioxidant capacity. ► However, l -arginine in contrast to BHT decreases the endotoxin-induced liver injury. |
| doi_str_mv | 10.1016/j.etap.2011.08.014 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1382-6689 |
| ispartof | Environmental toxicology and pharmacology, 2011-11, Vol.32 (3), p.457-464 |
| issn | 1382-6689 1872-7077 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Arginine - pharmacology Butylated hydroxytoluene Butylated Hydroxytoluene - pharmacology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control Dose-Response Relationship, Drug Emergency Endotoxins - toxicity Escherichia coli Food Additives - pharmacology Glutathione Glutathione - metabolism Glutathione Peroxidase - metabolism l-Arginine Lipopolysaccharides Liver - drug effects Liver - metabolism Liver injury Male Nitrates - blood Nitric oxide Nitrites - blood Rats Rats, Wistar Superoxide Dismutase - metabolism |
| title | Effect of butylated hydroxytoluene (E321) pretreatment versus l -arginine on liver injury after sub-lethal dose of endotoxin administration |
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