Effect of butylated hydroxytoluene (E321) pretreatment versus l -arginine on liver injury after sub-lethal dose of endotoxin administration

Highlights ► Butylated hydroxytoluene (BHT or E321) is a widely used food antioxidant. ► It may accumulate in liver due to continual intake of BHT-protected foods. ► Consumption of enteric bacteria-contaminated foods may cause serious endotoxemia. ► In case of BHT accumulation, endotoxemia reduces l...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2011-11, Vol.32 (3), p.457-464
Hauptverfasser:	Engin, Ayse Basak, Bukan, Neslihan, Kurukahvecioglu, Osman, Memis, Leyla, Engin, Atilla
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - pharmacology Butylated hydroxytoluene Butylated Hydroxytoluene - pharmacology Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - prevention & control Dose-Response Relationship, Drug Emergency Endotoxins - toxicity Escherichia coli Food Additives - pharmacology Glutathione Glutathione - metabolism Glutathione Peroxidase - metabolism l-Arginine Lipopolysaccharides Liver - drug effects Liver - metabolism Liver injury Male Nitrates - blood Nitric oxide Nitrites - blood Rats Rats, Wistar Superoxide Dismutase - metabolism
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Beschreibung
Zusammenfassung:	Highlights ► Butylated hydroxytoluene (BHT or E321) is a widely used food antioxidant. ► It may accumulate in liver due to continual intake of BHT-protected foods. ► Consumption of enteric bacteria-contaminated foods may cause serious endotoxemia. ► In case of BHT accumulation, endotoxemia reduces liver antioxidant capacity. ► However, l -arginine in contrast to BHT decreases the endotoxin-induced liver injury.
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2011.08.014