Prevalence and genotypic characteristics of β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Australia

To determine the prevalence of β-lactamase-negative ampicillin-resistant (BLNAR) Haemophilus influenzae in Australia and characterize the associated amino acid substitutions in penicillin-binding protein 3. Two hundred consecutive non-repeat clinical isolates of H. influenzae were collected and β-la...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2011-05, Vol.66 (5), p.1013-1015
Hauptverfasser:	WITHERDEN, Elizabeth A, MONTGOMERY, Janet, HENDERSON, Barbara, TRISTRAM, Stephen G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Ampicillin - pharmacology Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Australia - epidemiology beta-Lactamases - biosynthesis Biological and medical sciences Haemophilus Infections - epidemiology Haemophilus Infections - microbiology Haemophilus influenzae Haemophilus influenzae - drug effects Haemophilus influenzae - enzymology Haemophilus influenzae - isolation & purification Humans Medical sciences Microbial Sensitivity Tests - methods Mutation, Missense Penicillin-Binding Proteins - genetics Pharmacology. Drug treatments Prevalence
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Zusammenfassung:	To determine the prevalence of β-lactamase-negative ampicillin-resistant (BLNAR) Haemophilus influenzae in Australia and characterize the associated amino acid substitutions in penicillin-binding protein 3. Two hundred consecutive non-repeat clinical isolates of H. influenzae were collected and β-lactamase-negative isolates were screened for reduced ampicillin susceptibility using an ampicillin 2 μg disc (breakpoint
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/dkr035