Low incidence of renal impairment observed in tenofovir-treated patients
To compare the incidence of renal impairment in HIV-infected patients exposed versus unexposed to tenofovir and to characterize risk factors associated with renal impairment. We undertook a retrospective cohort and nested case-control study of 514 Northwestern University HIV Outpatient Study partici...
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Veröffentlicht in: | Journal of antimicrobial chemotherapy 2011-05, Vol.66 (5), p.1120-1126 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To compare the incidence of renal impairment in HIV-infected patients exposed versus unexposed to tenofovir and to characterize risk factors associated with renal impairment.
We undertook a retrospective cohort and nested case-control study of 514 Northwestern University HIV Outpatient Study participants who received antiretroviral therapy (ART) between 1 August 2001 and 31 July 2007. Renal impairment was defined as meeting at least one of two validated criteria based on serum creatinine, calculated glomerular filtration rate and creatinine clearance. Multivariable analysis was performed to identify risk factors for renal impairment.
Renal impairment occurred in 14% (n = 72) of the cohort and was not correlated with exposure to tenofovir in univariate analyses. In multivariable analysis, more advanced age [odds ratio (OR) = 1.04, P = 0.02], diabetes (OR = 3.6, P |
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ISSN: | 0305-7453 1460-2091 |
DOI: | 10.1093/jac/dkr039 |