HIV–HBV vaccine escape mutant infection with loss of HBV surface antibody and persistent HBV viremia on tenofovir/emtricitabine without antiviral resistance

Abstract We report a case of acute hepatitis B virus genotype A vaccine escape mutant infection with loss of HBV vaccine-induced seropositivity in a HIV-1 infected patient. His HBV is unresponsive to tenofovir/emtricitabine treatment demonstrated by persistent viremia despite lacking known resistanc...

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Veröffentlicht in:	Journal of clinical virology 2011-11, Vol.52 (3), p.261-264
Hauptverfasser:	Schirmer, P, Winters, M, Holodniy, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - analogs & derivatives Adenine - therapeutic use Allergy and Immunology Antiviral Agents - administration & dosage Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Biological and medical sciences Coinfection - virology Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Drug Resistance, Viral Emtricitabine Fundamental and applied biological sciences. Psychology HBV Hepatitis B - complications Hepatitis B - immunology Hepatitis B - virology Hepatitis B Antibodies - immunology Hepatitis B e Antigens - immunology Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology Hepatitis B Vaccines - immunology Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B virus - pathogenicity HIV HIV Infections - complications HIV-1 Human immunodeficiency virus 1 Human viral diseases Humans Infectious Disease Infectious diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Mutation Organophosphonates - administration & dosage Organophosphonates - therapeutic use Tenofovir Vaccine escape Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Viremia - drug therapy Viremia - virology Virology
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Zusammenfassung:	Abstract We report a case of acute hepatitis B virus genotype A vaccine escape mutant infection with loss of HBV vaccine-induced seropositivity in a HIV-1 infected patient. His HBV is unresponsive to tenofovir/emtricitabine treatment demonstrated by persistent viremia despite lacking known resistance mutations and while having an undetectable HIV-1 viral load.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2011.07.014