Sympathetic inhibition of IL-6, IFN-γ, and KC/CXCL1 and sympathetic stimulation of TGF-β in spleen of early arthritic mice

Highlight ► In early arthritis, studying neuroimmune communication in superfused spleen slices revealed that TGF-β is strongly increased by local sympathetic β-adrenergic pathways.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2011-11, Vol.25 (8), p.1708-1715
Hauptverfasser:	Straub, Rainer H, Rauch, Luise, Rauh, Lena, Pongratz, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A1 Receptor Antagonists - pharmacology Adrenergic alpha-1 Receptor Antagonists - pharmacology Adrenergic beta-Antagonists - pharmacology Allergy and Immunology Animals Arthritis Arthritis, Experimental - chemically induced Arthritis, Experimental - physiopathology Autonomic Pathways - drug effects Autonomic Pathways - physiology Chemokine CXCL1 - analysis Chemokine CXCL1 - physiology Collagen Type II Electric Stimulation Female IL-6 Interferon-gamma - analysis Interferon-gamma - physiology Interleukin-6 - analysis Interleukin-6 - biosynthesis Interleukin-6 - physiology Magnetic Resonance Imaging Mice Mice, Inbred DBA Psychiatry Signal Transduction - drug effects Spleen Spleen - drug effects Spleen - innervation Spleen - physiology Sympathetic nervous system Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology TGF-β Transforming Growth Factor beta - biosynthesis
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Beschreibung
Zusammenfassung:	Highlight ► In early arthritis, studying neuroimmune communication in superfused spleen slices revealed that TGF-β is strongly increased by local sympathetic β-adrenergic pathways.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2011.07.001