Characterization of foot-and-mouth disease virus from outbreaks in Ecuador during 2009–2010 and cross-protection studies with the vaccine strain in use in the region

Highlights ► First antigenic/genetic characterization of type O FMD recent viruses in Ecuador. ► In vivo challenge studies indicated lack of appropriate protection by vaccines in use. ► In vitro vaccine matching studies also showed loss of protective response. ► Rapid and sensitive results on antige...

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Veröffentlicht in:	Vaccine 2011-10, Vol.29 (46), p.8230-8240
Hauptverfasser:	Maradei, Eduardo, Perez Beascoechea, Claudia, Malirat, Viviana, Salgado, Gustavo, Seki, Cristina, Pedemonte, Andrea, Bonastre, Paula, D’Aloia, Ricardo, La Torre, José L, Mattion, Nora, Rodríguez Toledo, Jorge, Bergmann, Ingrid E
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Monoclonal - immunology Antibodies, Viral - immunology Applied microbiology Biological and medical sciences Capsid Proteins - genetics Cattle Cattle Diseases - epidemiology Cluster Analysis Cross Protection Disease Outbreaks Ecuador - epidemiology Foot & mouth disease foot-and-mouth disease Foot-and-Mouth Disease - epidemiology Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - classification Foot-and-Mouth Disease Virus - genetics Foot-and-Mouth Disease Virus - isolation & purification Fundamental and applied biological sciences. Psychology Genotype Microbiology Miscellaneous Molecular epidemiology Molecular Sequence Data monoclonal antibodies Monoclonal antibody profiling neutralization Phylogeny RNA, Viral - genetics Sequence Analysis, DNA Sequence Homology serotypes Serotyping Vaccine matching Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Values Viral Vaccines - immunology Virology Viruses
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Beschreibung
Zusammenfassung:	Highlights ► First antigenic/genetic characterization of type O FMD recent viruses in Ecuador. ► In vivo challenge studies indicated lack of appropriate protection by vaccines in use. ► In vitro vaccine matching studies also showed loss of protective response. ► Rapid and sensitive results on antigenic differences were obtained by MAbs profiling. ► A particularly unusual codon deletion appeared in VP1 protein of some viruses.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.08.120