HLA class II transgenic mice develop a safe and long lasting immune response against StreptInCor, an anti-group A streptococcus vaccine candidate

Highlights ► HLA class II transgenic mice are important model for study the role of human HLA class II molecules in animal model. ► Long lasting immune response (1 year) indicated that StreptInCor vaccine epitope induces a robust immune response. ► StreptInCor did not induce heart tissue cross react...

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Veröffentlicht in:	Vaccine 2011-10, Vol.29 (46), p.8250-8256
Hauptverfasser:	Guerino, Milton T, Postol, Edilberto, Demarchi, Lea M.F, Martins, Carlo O, Mundel, Luiz R, Kalil, Jorge, Guilherme, Luiza
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Allergy and Immunology Alum Compounds - administration & dosage Aluminum Amino acids Animal models Animal Structures - pathology Animals Antibodies, Bacterial - blood Antigens, Bacterial - genetics Antigens, Bacterial - immunology Applied microbiology Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - immunology Biological and medical sciences blood Carrier Proteins - genetics Carrier Proteins - immunology Colleges & universities Complications complications (disease) double prime M protein Epitopes Epitopes - genetics Epitopes - immunology Female fever Fundamental and applied biological sciences. Psychology heart diseases Histocompatibility antigen HLA Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - immunology Histocytochemistry Histopathology HLA class II transgenic mice Humans Humoral immune response Immune response Immune system Immunization Immunoglobulin A - blood Immunoglobulin G - blood Infection Lymphocytes B Male Mice Mice, Transgenic Microbiology Microscopy Mortality Peptides Proteins Rheumatic fever Rheumatic heart disease Rodents S. pyogenes Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - adverse effects Streptococcal Vaccines - immunology Streptococcus pyogenes Streptococcus pyogenes - genetics Streptococcus pyogenes - immunology T cell receptors Transgenic animals Transgenic mice Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:	Highlights ► HLA class II transgenic mice are important model for study the role of human HLA class II molecules in animal model. ► Long lasting immune response (1 year) indicated that StreptInCor vaccine epitope induces a robust immune response. ► StreptInCor did not induce heart tissue cross reactive antibodies. ► Histopathology analysis after one year post-immunization indicated that StreptInCor vaccine epitope is safe.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.08.113