Modeling the decline in pneumococcal acute otitis media following the introduction of pneumococcal conjugate vaccines in the US

Highlights ► We hypothesized serotype replacement has resulted in fewer episodes of SP-AOM. ► We modeled the change in proportion of SP colonized children who would develop SP-AOM. ► Our model is based on changing nasopharyngeal serotype distributions and serotype invasiveness. ► Analysis indicates...

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Veröffentlicht in:	Vaccine 2011-10, Vol.29 (45), p.8042-8048
Hauptverfasser:	Shea, K.M, Weycker, D, Stevenson, A.E, Strutton, D.R, Pelton, S.I
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute otitis media Allergy and Immunology Applied microbiology Bacteriology Biological and medical sciences Carrier State - epidemiology Carrier State - microbiology Child, Preschool children Children & youth disease prevalence Fundamental and applied biological sciences. Psychology Heptavalent Pneumococcal Conjugate Vaccine Humans Immunization Incidence Infant Microbiology Miscellaneous Models, Statistical nasopharynx Nasopharynx - microbiology otitis media Otitis Media - epidemiology Otitis Media - microbiology Pneumococcal Infections - epidemiology Pneumococcal Infections - microbiology Pneumococcal vaccine Pneumococcal Vaccines - administration & dosage Pneumococcal Vaccines - immunology Pneumonia Serotype replacement serotypes Serotyping Streptococcus pneumoniae Streptococcus pneumoniae - classification Streptococcus pneumoniae - isolation & purification United States - epidemiology vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights ► We hypothesized serotype replacement has resulted in fewer episodes of SP-AOM. ► We modeled the change in proportion of SP colonized children who would develop SP-AOM. ► Our model is based on changing nasopharyngeal serotype distributions and serotype invasiveness. ► Analysis indicates 12% decline in pneumococcal AOM in young children between 2000 and 2007. ► Analysis predicts PCV13 will further decrease pneumococcal AOM additional 27% from 2007 to 2013.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.08.057