Assessment of IgG antibodies to oxidized LDL in patients with acute coronary syndrome

Objectives. Circulating IgG antibodies to oxidized low-density lipoprotein (anti-oxLDL) have been implicated in the development of atherosclerotic plaques. In this study, we investigated the prognostic value of IgG anti-oxLDL antibodies in patients with acute coronary syndrome (ACS). Methods. In tot...

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Veröffentlicht in:	Lupus 2011-06, Vol.20 (7), p.730-735
Hauptverfasser:	Laczik, R, Szodoray, P, Veres, K, Szomják, E, Csípő, I, Sipka, S, Shoenfeld, Y, Szekanecz, Z, Soltész, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - blood Acute Coronary Syndrome - drug therapy Acute Coronary Syndrome - immunology Acute coronary syndromes Adult Aged Antibodies Arrhythmia Arteriosclerosis Atherosclerosis Autoantibodies - immunology Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Heart Heart attacks Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Immunoglobulin G Immunoglobulin G - blood Immunology Internal medicine Lipids Lipoproteins Lipoproteins (low density) Lipoproteins, LDL - immunology Male Medicine Middle Aged Pain Plaque, Atherosclerotic - immunology Plaques Prognosis Prospective Studies Science Statins
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Zusammenfassung:	Objectives. Circulating IgG antibodies to oxidized low-density lipoprotein (anti-oxLDL) have been implicated in the development of atherosclerotic plaques. In this study, we investigated the prognostic value of IgG anti-oxLDL antibodies in patients with acute coronary syndrome (ACS). Methods. In total 54 patients with ACS and 41 matched healthy controls were involved in this prospective study. Serum IgG anti-oxLDL levels were assessed by ELISA. Results. Higher IgG anti-oxLDL levels were found in patients with ACS versus controls (22.8 ± 23.3 vs. 7.5 ± 5.27 EU/ml, p
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203311398884