Quantitative determination of residual 2-(2-chloroethoxy) ethanol (CEE) in quetiapine fumarate by gas chromatogaraphy

Quantitative determination of residual 2-(2-chloroethoxy) ethanol (CEE) in quetiapine fumarate by gas chromatogaraphy

A simple and specific gas chromatographic method was developed and validated for the determination of 2-(2-chloroethoxy) ethanol in Quetiapine Fumarate. The method was carried out with a flame ionization detector and DB-FFAP capillary column. The linearity was established over a range of 40-150 mu g...

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Veröffentlicht in:Advances in bioscience and biotechnology 2010-12, Vol.1 (5), p.367-371
Hauptverfasser: Tiwari, Pravish, Yadav, Ravi, Sathe, Padmakar A., Gangrade, Deepali
Format: Artikel
Sprache:eng
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Zusammenfassung:A simple and specific gas chromatographic method was developed and validated for the determination of 2-(2-chloroethoxy) ethanol in Quetiapine Fumarate. The method was carried out with a flame ionization detector and DB-FFAP capillary column. The linearity was established over a range of 40-150 mu g ml-1 and correlation coefficient is more than 0.999.
ISSN:2156-8456
2156-8502
DOI:10.4236/abb.2010.15049