MRI shows increased sciatic nerve cross sectional area in inherited and inflammatory neuropathies

Measurements of the cross sectional area of the sciatic nerve are described in a group of 10 patients with genetically confirmed Charcot–Marie–Tooth disease type 1A (CMT1A), nine patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 10 healthy controls using MRI. One mid-thigh o...

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Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2011-11, Vol.82 (11), p.1283-1286
Hauptverfasser:	Sinclair, C D J, Miranda, M A, Cowley, P, Morrow, J M, Davagnanam, I, Mehta, H, Hanna, M G, Koltzenburg, M, Reilly, M M, Yousry, T A, Thornton, J S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Ankle Biological and medical sciences Case-Control Studies Charcot-Marie-Tooth Disease - genetics Charcot-Marie-Tooth Disease - physiopathology Cranial nerves. Peripheral nerves. Autonomic nervous system Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Female Humans Hypertrophy Inflammation Injuries of the nervous system and the skull. Diseases due to physical agents Magnetic Resonance Imaging - methods Male Medical research Medical sciences Middle Aged Nerve Degeneration - genetics Nerve Degeneration - physiopathology Nervous system (semeiology, syndromes) Neurology Neurosurgery Patients Peripheral Nervous System Diseases - genetics Peripheral Nervous System Diseases - physiopathology Peripheral neuropathy Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - genetics Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - physiopathology Sciatic Nerve - pathology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Traumas. Diseases due to physical agents
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Zusammenfassung:	Measurements of the cross sectional area of the sciatic nerve are described in a group of 10 patients with genetically confirmed Charcot–Marie–Tooth disease type 1A (CMT1A), nine patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and 10 healthy controls using MRI. One mid-thigh of each individual was imaged using a short tau inversion recovery sequence and the nerve appearance evaluated radiologically with respect to the signal intensity and visibility of the internal neural structure. The cross sectional area of the sciatic nerve of each individual was measured by defining irregular enclosing regions of interest on the MRI images. The sciatic nerve area was enlarged in both CMT1A (p
ISSN:	0022-3050 1468-330X
DOI:	10.1136/jnnp.2010.211334