Efficacy and safety of raltegravir in treatment-experienced HIV-1-infected patients switching from enfuvirtide-based regimens: 48 week results of the randomized EASIER ANRS 138 trial

Objectives To assess the sustainable efficacy and safety of a switch from enfuvirtide to raltegravir in patients with multidrug-resistant HIV infection. Methods One hundred and seventy patients with multidrug-resistant HIV infection and suppressed plasma HIV RNA levels

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2011-09, Vol.66 (9), p.2099-2106
Hauptverfasser:	Gallien, Sébastien, Braun, Joséphine, Delaugerre, Constance, Charreau, Isabelle, Reynes, Jacques, Jeanblanc, François, Verdon, Renaud, de Truchis, Pierre, May, Thierry, Madelaine-Chambrin, Isabelle, Aboulker, Jean-Pierre, Molina, Jean-Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alanine Transaminase - blood Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences CD4 Lymphocyte Count Drug resistance Drug Resistance, Multiple, Viral Endpoint Determination Female France Genotype HIV HIV Envelope Protein gp41 - therapeutic use HIV Fusion Inhibitors HIV Infections - blood HIV Infections - drug therapy HIV Infections - virology HIV Integrase Inhibitors - adverse effects HIV Integrase Inhibitors - therapeutic use HIV-1 Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Medical treatment Microbial Sensitivity Tests Middle Aged Peptide Fragments - therapeutic use Pharmacology. Drug treatments Pilot Projects Plasma Prospective Studies Pyrrolidinones - adverse effects Pyrrolidinones - therapeutic use Raltegravir Potassium Ribonucleic acid RNA RNA, Viral - blood Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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Beschreibung
Zusammenfassung:	Objectives To assess the sustainable efficacy and safety of a switch from enfuvirtide to raltegravir in patients with multidrug-resistant HIV infection. Methods One hundred and seventy patients with multidrug-resistant HIV infection and suppressed plasma HIV RNA levels
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/dkr269