Coproporphyrins, Uroporphyrins, and Their Metal Comlexes: Biosynthesis and Application to Immune Analysis and Diagnostic Methods

Coproporphyrins, Uroporphyrins, and Their Metal Comlexes: Biosynthesis and Application to Immune Analysis and Diagnostic Methods

Methods of synthesis of coproporphyrin and uroporphyrin by using bacteria of the genus Arthrobacterare proposed. Metal complexes of coproporphyrin and uroporphyrin with Pt, Pd, and Zn were synthesized. Their structures were identified by spectrophotometry, IR spectrometry, ^sup 1^H-NMR, mass spectro...

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Veröffentlicht in:Applied biochemistry and microbiology 2001-11, Vol.37 (6), p.561-568
Hauptverfasser: Bykhovsky, V Ya, Zaitseva, N I, Mironov, A F, Osin, N S, Pecherskikh, E V, Rumyantseva, V D, Sukhin, G M
Format: Artikel
Sprache:eng
Schlagworte:
Analytical chemistry
Biosynthesis
Chromatography
Liquid chromatography
Mass spectrometry
Metal complexes
Spectrophotometry
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Zusammenfassung:Methods of synthesis of coproporphyrin and uroporphyrin by using bacteria of the genus Arthrobacterare proposed. Metal complexes of coproporphyrin and uroporphyrin with Pt, Pd, and Zn were synthesized. Their structures were identified by spectrophotometry, IR spectrometry, ^sup 1^H-NMR, mass spectrometry, and HPLC. Data showing the possibility of using coproporphyrin III-metal complexes as luminophores for fluorescence detection of tumors was gathered. The current and prospective uses of metal complexes of water-soluble natural porphyrins in advanced immunofluorescence assays are discussed.[PUBLICATION ABSTRACT]
ISSN:0003-6838
1608-3024
DOI:10.1023/A:1012342815215