SHARPINing integrin inhibition

SHARPINing integrin inhibition

The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering...

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Veröffentlicht in:Nature cell biology 2011-11, Vol.13 (11), p.1292-1293
1. Verfasser: Bass, Mark D.
Format: Artikel
Sprache:eng
Schlagworte:
631/57/2272
631/80/79/1236
Adhesion
Animals
Biomedical and Life Sciences
Cancer Research
Cell Biology
Developmental Biology
Genes
Humans
Integrin beta1 - metabolism
Integrins
Life Sciences
Nerve Tissue Proteins - metabolism
news-and-views
Physiological aspects
Stem Cells
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Beschreibung
Zusammenfassung:The activity state of integrins is crucial for cell adhesion, migration and differentiation, and is regulated predominantly by protein interactions of the integrin β cytoplasmic domain. SHARPIN is now shown to negatively regulate integrin activation by binding the α-integrin subunit and interfering with the association of the β cytodomain with activating proteins.
ISSN:1465-7392
1476-4679
DOI:10.1038/ncb2368