combination chemotherapy protocol with dose intensification and autologous bone marrow transplant (VELCAP-HDC) for canine lymphoma

Twenty‐eight dogs with lymphoma were treated with a 12‐week, 5‐drug chemotherapy protocol concluding with high‐dose cyclophosphamide supported by autologous bone marrow transplants. A dose escalation design was used to determine the maximum tolerated cyclophosphamide dose (MTD) in this setting. Thre...

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Veröffentlicht in:Journal of veterinary internal medicine 2006-03, Vol.20 (2), p.355-364
Hauptverfasser: Frimberger, A.E, Moore, A.S, Rassnick, K.M, Cotter, S.M, O'Sullivan, J.L, Quesenberry, P.J
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Sprache:eng
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Zusammenfassung:Twenty‐eight dogs with lymphoma were treated with a 12‐week, 5‐drug chemotherapy protocol concluding with high‐dose cyclophosphamide supported by autologous bone marrow transplants. A dose escalation design was used to determine the maximum tolerated cyclophosphamide dose (MTD) in this setting. Three cyclophosphamide dose levels were given: 300 mg/ m2 IV (group1, 3 dogs), 400 mg/m2 IV (group 2, 12 dogs), and 500 mg/m2 IV (group 3, 13 dogs); and the MTD was 500 mg/m2 IV. Toxicity was common but mild, and the dose‐limiting toxicity was myelosuppression, specifically neutropenia. No dog died as a result of treatment‐related toxicity. One dog in group 3 developed fever, neutropenia, and presumed sepsis and responded promptly to routine management. No other dog required hospitalization. Lower stage and higher cyclophosphamide dose (both increasing dose [study groups 1–3], and the highest dose [group 3]) compared with the lower doses combined (groups 1 and 2) were significantly associated with longer remission duration (all P
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2006.tb02868.x