Quantification improves the prognostic value of CD38 expression in B‐cell chronic lymphocytic leukaemia

Recent studies have shown that CD38 expressed as a percentage of the antigen positivity can predict prognosis and disease progression in patients with B‐cell chronic lymphocytic leukaemia (B‐CLL). The present study showed that quantification of CD38 expressed as antibody‐binding capacity (ABC) improves the prognostic value of the percentage of CD38 positivity in B‐CLL. In a cohort of 81 patients with B‐CLL, a level of CD38 expression of ≥ 30% and an ABC value of 250 proved statistically valid cut‐off points to predict disease progression (% CD38: P=0·0027; ABC: P