Recent progress in microfluidic devices for nucleic acid and antibody assays

Microfluidic devices are increasingly important in biomedical assays. In this paper, we review recent progress on these devices for chemical amplification, hybridization, separation, and detection of nucleic acids. Recent developments in microfluidic technologies for detection of protein binding eve...

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Veröffentlicht in:	Proceedings of the IEEE 2003, Vol.91 (6), p.954-975
Hauptverfasser:	Selvaganapathy, P.R., Carlen, E.T., Mastrangelo, C.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amplification Antibodies Assaying Binding Biochemistry Chemicals Devices DNA Genetics Immune system Immunoassay Laboratories Microfluidics Micromechanical devices Nucleic acids Performance analysis Proteins
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Beschreibung
Zusammenfassung:	Microfluidic devices are increasingly important in biomedical assays. In this paper, we review recent progress on these devices for chemical amplification, hybridization, separation, and detection of nucleic acids. Recent developments in microfluidic technologies for detection of protein binding events in immunoassay applications are also reviewed.
ISSN:	0018-9219 1558-2256
DOI:	10.1109/JPROC.2003.813569