NMR and conformational studies of new 5-phenylpyrrole-carboxamide derivatives

The 1H and 13C NMR resonances of 22 5‐(5‐substituted‐2‐nitrophenyl)‐1H‐pyrrole‐2‐carboxamides, 22 5‐(5‐substituted‐2‐aminophenyl)‐1H‐pyrrole‐2‐carboxamides, and 9 5‐phenyl‐1H‐pyrrole‐2‐carboxamides were assigned completely using the concerted application of one‐ and two‐dimensional experiments (DEPT, gs‐HMQC and gs‐HMBC). NOE studies and conformational analysis confirm the preferred conformations of such compounds. Copyright © 2009 John Wiley & Sons, Ltd. The 1H and 13C NMR resonances of 53 5‐(2,5‐disubstitutedphenyl)‐1H‐pyrrole‐2‐carboxamides were assigned completely. NOE studies and conformational analysis confirm the preferred conformation of such compounds.