Mass spectral analysis of N-oxides of Chemical Weapons Convention related aminoethanols under electrospray ionization conditions

N,N'‐Dialkylaminoethanols are the hydrolyzed products or precursors of chemical warfare agents such as V‐agents and nitrogen mustards, and they are prone to undergo oxidation in environmental matrices or during decontamination processes. Consequently, screening of the oxidized products of aminoethanols in aqueous samples is an important task in the verification of chemical weapons convention‐related chemicals. Here we report the successful characterization of the N‐oxides of N,N'‐dialkylaminoethanols, alkyl diethanolamines, and triethanolamine using positive ion electrospray ionization mass spectrometry. The collision‐induced dissociation (CID) spectra of the [M + H]+ and [M + Na]+ ions show diagnostic product ions that enable the unambiguous identification of the studied N‐oxides, including those of isomeric compounds. The proposed fragmentation pathways are supported by high‐resolution mass spectrometry data and product/precursor ion spectra. The CID spectra of [M + H]+ ions included [MH − CH4O2]+ as the key product ion, in addition to a distinctive alkene loss that allowed us to recognize the alkyl group attached to the nitrogen. The [M + Na]+ ions show characteristic product ions due to the loss of groups (R) attached to nitrogen either as a radical (1R.) or as a molecule [R + H or (R − H)] after hydrogen migration. Copyright © 2011 John Wiley & Sons, Ltd.