Synthesis and complete assignment of NMR data of 20 chalcones

Chalcones, intermediates in flavonoid biosynthesis, can exhibit antibacterial, antiproliferative, and anti‐inflammatory properties. Chalcones contain two benzene rings and both hydroxylated and methoxylated analogs are frequently produced by hydroxylases and O‐methyltransferases in plant biosynthetic pathways. Assignments of NMR peaks in the spectra of hydroxylated and/or methoxylated chalcones can help in identifying novel chalcone derivatives isolated from natural sources by referencing these data against NMR spectra obtained from known chalcones. We report here the syntheses of 20 chalcones and complete assignments of 1H and 13C NMR spectra. Copyright © 2010 John Wiley & Sons, Ltd. Chalcones, intermediates in flavonoid biosyntheses, can exhibit antibacterial, antiproliferative, and anti‐inflammatory properties. Assignments of NMR peaks in the spectra of hydroxylated and/or methoxylated chalcones can help in identifying novel chalcone derivatives isolated from natural sources by referencing these data against NMR spectra obtained from known chalcones. We report here the syntheses of 20 chalcones and complete assignments of 1H and 13C NMR spectra.