Iron Deficiency Predicts Impaired Exercise Capacity in Patients With Systolic Chronic Heart Failure

Iron Deficiency Predicts Impaired Exercise Capacity in Patients With Systolic Chronic Heart Failure

Abstract Background Iron is an indispensable element of hemoglobin, myoglobin, and cytochromes, and, beyond erythropoiesis, is involved in oxidative metabolism and cellular energetics. Hence, iron deficiency (ID) is anticipated to limit exercise capacity. We investigated whether ID predicted exercis...

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Veröffentlicht in:Journal of cardiac failure 2011-11, Vol.17 (11), p.899-906
Hauptverfasser: Jankowska, Ewa A., MD, PhD, FESC, Rozentryt, Piotr, MD, Witkowska, Agnieszka, MD, Nowak, Jolanta, MD, Hartmann, Oliver, Ponikowska, Beata, MD, PhD, Borodulin-Nadzieja, Ludmila, MD, PhD, von Haehling, Stephan, MD, PhD, Doehner, Wolfram, MD, PhD, Banasiak, Waldemar, MD, PhD, FESC, Polonski, Lech, MD, PhD, Filippatos, Gerasimos, MD, PhD, FESC, Anker, Stefan D., MD, PhD, FESC, Ponikowski, Piotr, MD, PhD, FESC
Format: Artikel
Sprache:eng
Schlagworte:
anemia
Cardiovascular
Chronic heart failure
Confidence Intervals
exercise intolerance
Exercise Test
Exercise Tolerance - physiology
Female
Ferritins - blood
Health Status Indicators
Heart Failure, Systolic - blood
Heart Failure, Systolic - physiopathology
Humans
Iron - deficiency
Male
Middle Aged
Multivariate Analysis
Oxygen Consumption
Prognosis
Prospective Studies
Risk Factors
Stroke Volume
Ventricular Function, Left
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Zusammenfassung:Abstract Background Iron is an indispensable element of hemoglobin, myoglobin, and cytochromes, and, beyond erythropoiesis, is involved in oxidative metabolism and cellular energetics. Hence, iron deficiency (ID) is anticipated to limit exercise capacity. We investigated whether ID predicted exercise intolerance in patients with systolic chronic heart failure (CHF). Methods and Results We prospectively studied 443 patients with stable systolic CHF (age 54 ± 10 years, males 90%, ejection fraction 26 ± 7%, New York Heart Association Class I/II/III/IV 49/188/180/26). ID was defined as: serum ferritin
ISSN:1071-9164
1532-8414
DOI:10.1016/j.cardfail.2011.08.003