Measuring the multi-scale integration of mechanical forces during morphogenesis

Measuring the multi-scale integration of mechanical forces during morphogenesis

Highlights ► We identify six developmentally-important morphogenetic spatial scales. ► Cell-intrinsic mechanical forces integrate up spatial scales. ► Extrinsic forces elicit passive responses down spatial scales. ► Non-linear cell behaviour can result from cells sensing mechanical cues. ► Automated...

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Veröffentlicht in:Current opinion in genetics & development 2011-10, Vol.21 (5), p.653-663
Hauptverfasser: Blanchard, Guy B, Adams, Richard J
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biophysical Phenomena
Intracellular Space
Medical Education
Morphogenesis
Nonlinear Dynamics
Stress, Mechanical
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Zusammenfassung:Highlights ► We identify six developmentally-important morphogenetic spatial scales. ► Cell-intrinsic mechanical forces integrate up spatial scales. ► Extrinsic forces elicit passive responses down spatial scales. ► Non-linear cell behaviour can result from cells sensing mechanical cues. ► Automated image analysis methods now allow multi-scale approaches.
ISSN:0959-437X
1879-0380
DOI:10.1016/j.gde.2011.08.008