Dedifferentiated adamantinoma associated with fibrous dysplasia

Summary A 21-year-old patient presented with an aggressive lesion of the left tibia associated to lymph nodes and lung metastasis. Histological examination revealed a high grade spindle cell sarcoma involving some areas of cytokeratine positive cells. Ultrastructural examination showed the presence...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Orthopaedics & traumatology, surgery & research surgery & research, 2011-11, Vol.97 (7), p.770-775
Hauptverfasser: Nouri, H, Jaafoura, H, Bouaziz, M, Ouertatani, M, Abid, L, Meherzi, M.H, Ladeb, M.F, Mestiri, M
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Summary A 21-year-old patient presented with an aggressive lesion of the left tibia associated to lymph nodes and lung metastasis. Histological examination revealed a high grade spindle cell sarcoma involving some areas of cytokeratine positive cells. Ultrastructural examination showed the presence of epithelial features in the sarcomatoid cells. The diagnosis of dedifferentiated spindle-celled adamantinoma was established. A second lesion of the right tibia was diagnosed as fibrous dysplasia. The patient had a leg amputation. He died 2 years later with multiple lung and bone metastases. The diagnosis of dedifferentiated adamantinoma should be considered when a clinician is confronted with a tibial biopsy of a “keratin-positive sarcoma”. The association with fibrous dysplasia in this case is discussed.
ISSN:1877-0568
1877-0568
DOI:10.1016/j.otsr.2011.05.005