Fast and Protecting-Group-Free Synthesis of (±)-Subincanadine C

Fast and Protecting-Group-Free Synthesis of (±)-Subincanadine C

The first total synthesis of (±)-subincanadine C has been accomplished in a protecting-group-free fashion. This pentacyclic indole alkaloid was synthesized in six steps from the known intermediate 4, featuring Ni(COD)2-mediated intramolecular Michael addition as a key transformation.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2011-11, Vol.13 (21), p.5782-5783
Hauptverfasser: Yu, Fangmiao, Cheng, Bin, Zhai, Hongbin
Format: Artikel
Sprache:eng
Schlagworte:
Esters - chemistry
Indole Alkaloids - chemical synthesis
Molecular Structure
Time Factors
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Beschreibung
Zusammenfassung:The first total synthesis of (±)-subincanadine C has been accomplished in a protecting-group-free fashion. This pentacyclic indole alkaloid was synthesized in six steps from the known intermediate 4, featuring Ni(COD)2-mediated intramolecular Michael addition as a key transformation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202349g