Farinamycin, a Quinazoline from Streptomyces griseus

The metabolic potential of a Streptomyces griseus strain was investigated under various cultivation conditions. After fermentation in a flour-based medium, a new quinazoline metabolite, farinamycin (1), could be isolated from the bacterium, which was previously known only for the production of pheno...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2011-10, Vol.74 (10), p.2265-2268
Hauptverfasser:	Nett, Markus, Hertweck, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Applied microbiology Bacillus subtilis - drug effects Biological and medical sciences Candida albicans - drug effects Drug Screening Assays, Antitumor Escherichia coli - drug effects Female Fermentation Fundamental and applied biological sciences. Psychology HeLa Cells Humans Microbial Sensitivity Tests Microbiology Molecular Structure Mycobacterium - drug effects Oxazines - chemistry Penicillium chrysogenum - drug effects Pseudomonas aeruginosa - drug effects Quinazolines - chemistry Quinazolines - isolation & purification Quinazolines - pharmacology Staphylococcus aureus - drug effects Streptomyces griseus Streptomyces griseus - chemistry
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Zusammenfassung:	The metabolic potential of a Streptomyces griseus strain was investigated under various cultivation conditions. After fermentation in a flour-based medium, a new quinazoline metabolite, farinamycin (1), could be isolated from the bacterium, which was previously known only for the production of phenoxazinone antibiotics. The structure of 1 illuminates the biosynthetic versatility of S. griseus, which assembles a defined set of building blocks into structurally diverse natural products.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np2002513