Scalarane Sesterterpenes from the Sponge Smenospongia sp

Ten new sesterterpene compounds (4−13) and seven known metabolites (1−3, 14−17) were isolated from the sponge Smenospongia sp. collected from Korean coastal waters. On the basis of combined spectroscopic analyses, the new compounds exhibited diverse functionalities on a common scalarane sesterterpen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-11, Vol.71 (11), p.1866-1871
Hauptverfasser:	Song, Jueun, Jeong, Wooyeol, Wang, Nan, Lee, Hyi-Seung, Sim, Chung J, Oh, Ki-Bong, Shin, Jongheon
Format:	Artikel
Sprache:	eng
Schlagworte:	acetoxyscalarin acetylscalarin Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology anticarcinogenic activity Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences chemical structure cultured cells cytotoxicity Drug Screening Assays, Antitumor enzyme inhibition furanosesterterpenes General pharmacology Humans hydroxyheteronemin isocitrate lyase Isocitrate Lyase - antagonists & inhibitors K562 Cells Medical sciences medicinal properties Microbial Sensitivity Tests Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera Porifera - chemistry scalarane sesquiterpenes sesquiterpenoids Sesterterpenes - chemistry Sesterterpenes - isolation & purification Sesterterpenes - pharmacology smenospongia spectral analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Ten new sesterterpene compounds (4−13) and seven known metabolites (1−3, 14−17) were isolated from the sponge Smenospongia sp. collected from Korean coastal waters. On the basis of combined spectroscopic analyses, the new compounds exhibited diverse functionalities on a common scalarane sesterterpene structure. The presence of a 23-aldehyde on compound 6 and a 20-carboxylic acid on 11 is unprecedented among sponge-derived scalarane sesterterpenes. Several of the new compounds showed significant cytotoxicity and antimicrobial activity, as well as moderate inhibitory activity against isocitrate lyase.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np8003694