Water-Soluble Prodrug of Antimicrotubule Agent Plinabulin: Effective Strategy with Click Chemistry

Click for improved solubility: A water‐soluble prodrug of plinabulin was designed and synthesized efficiently by using click chemistry in three steps (see scheme). The product was highly water‐soluble, and the parent compound could be regenerated by esterase hydrolysis.

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Veröffentlicht in:Chemistry : a European journal 2011-11, Vol.17 (45), p.12587-12590
Hauptverfasser: Yakushiji, Fumika, Tanaka, Hironari, Muguruma, Kyohei, Iwahashi, Takahiro, Yamazaki, Yuri, Hayashi, Yoshio
Format: Artikel
Sprache:eng
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Zusammenfassung:Click for improved solubility: A water‐soluble prodrug of plinabulin was designed and synthesized efficiently by using click chemistry in three steps (see scheme). The product was highly water‐soluble, and the parent compound could be regenerated by esterase hydrolysis.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201102293