Metformin As a Geroprotector

Metformin As a Geroprotector

Geroprotectors are drugs that decrease the rate of aging and therefore extend life span. Metformin has been described as a geroprotector, and several studies have shown that metformin can slow down the rate of aging. The mechanisms behind the geroprotective effect of metformin are less established....

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Veröffentlicht in:Rejuvenation research 2011-10, Vol.14 (5), p.469-482
1. Verfasser: Bulterijs, Sven
Format: Artikel
Sprache:eng
Schlagworte:
Aging - drug effects
Animals
Apoptosis
Caloric Restriction
Care and treatment
Genetic aspects
Geriatrics
Glucose metabolism
Health aspects
Humans
Longevity - drug effects
Macular degeneration
Metformin
Metformin - chemistry
Metformin - pharmacology
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Zusammenfassung:Geroprotectors are drugs that decrease the rate of aging and therefore extend life span. Metformin has been described as a geroprotector, and several studies have shown that metformin can slow down the rate of aging. The mechanisms behind the geroprotective effect of metformin are less established. The goal of this review is to investigate the evidence for the geroprotective effect of metformin and to describe the possible mechanisms behind it.
ISSN:1549-1684
1557-8577
DOI:10.1089/rej.2011.1153