Evidence for autonomic nervous system dysfunction in females with idiopathic overactive bladder syndrome
Aims Micturition and continence are largely under the control of the autonomic nervous system (ANS). In this study, we analyzed ANS function using autonomic cardiovascular (CV) testing in females with idiopathic overactive bladder syndrome (iOAB) versus control females. Our hypothesis was that ANS d...
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Veröffentlicht in: | Neurourology and urodynamics 2011-11, Vol.30 (8), p.1467-1472 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Aims
Micturition and continence are largely under the control of the autonomic nervous system (ANS). In this study, we analyzed ANS function using autonomic cardiovascular (CV) testing in females with idiopathic overactive bladder syndrome (iOAB) versus control females. Our hypothesis was that ANS dysfunction could comprise part of the pathophysiology of iOAB.
Methods
Twenty‐three females with iOAB and 29 controls were enrolled into this prospective study. Patients performed CV autonomic testing, including two sympathetic tests (hand grip exercise and cold pressor test), two parasympathetic tests (deep breathing and 30:15 ratio), and two mixed tests (Valsalva manoeuvre and blood pressure [BP] response to standing). Patients with iOAB also underwent conventional urodynamic studies in order to define iOAB as either with or without demonstrable detrusor overactivity (DO).
Results
Both groups were similar with respect to age and menopausal status. Females with iOAB had significantly more positive tests than controls (P |
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ISSN: | 0733-2467 1520-6777 |
DOI: | 10.1002/nau.21154 |