Prenatal risk stratification for isolated congenital diaphragmatic hernia: results of a Japanese multicenter study

Abstract Background/Purpose The aim of this study was to establish a prenatal prognostic classification system for risk-stratified management in fetuses with isolated congenital diaphragmatic hernia (CDH). Methods A multi-institutional retrospective cohort study of isolated CDH, diagnosed prenatally in fetuses delivered during the 2002 to 2007 period at 5 participating institutions in Japan, was conducted. The risk stratification system was formulated based on the odds ratios of prenatal parameters for mortality at 90 days. The clinical severity in CDH infants were compared among the stratified risk groups. Results Patients were classified into the 3 risk groups: group A (n = 48) consisted of infants showing liver-down with contralateral lung–to–thorax transverse area ratio (L/T) ratio ≥0.08; group B of infants showing liver-down with L/T ratio