Interactions between the renin-angiotensin system and catecholamines on the cardiovascular system of elasmobranchs

The interaction between homologous dogfish angiotensin II ([Asn super(1), Pro super(3), Ile super(5)]-AngII) and catecholamines was examined using blood pressure bioassay. Both noradrenaline and [Asn super(1), Pro super(3), Ile super(5)]-Ang II elicited a pressor response. Pre-treatment with phentol...

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Veröffentlicht in:	Fish physiology and biochemistry 1997-12, Vol.17 (1-6), p.333-337
Hauptverfasser:	Tierney, M.L. (St.-Andrews Univ., St.-Andrews, Fife (United Kingdom). Gatty Marine Lab.), Hamano, K, Anderson, G, Takei, Y, Ashida, K, Hazon, N
Format:	Artikel
Sprache:	eng
Schlagworte:	AIGUILLAT ANGIOTENSIN ANGIOTENSINA ANGIOTENSINE Bioassays Blood pressure CARDIOVASCULAR SYSTEM CATECHOLAMINE CATECHOLAMINES CATECOLAMINAS DOGFISH Elasmobranchii SISTEMA CARDIOVASCULAR SYSTEME CARDIOVASCULAIRE TOLLO
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Zusammenfassung:	The interaction between homologous dogfish angiotensin II ([Asn super(1), Pro super(3), Ile super(5)]-AngII) and catecholamines was examined using blood pressure bioassay. Both noradrenaline and [Asn super(1), Pro super(3), Ile super(5)]-Ang II elicited a pressor response. Pre-treatment with phentolamine (1 mg kg super(-1)) completely abolished the noradrenaline pressor response but did not alter the magnitude of the [Asn super(1), Pro super(3), Ile super(5)]-Ang II pressor response although there was an initial delay in the response to [Asn super(1), Pro super(3), Ile super(5)]-Ang II. These results indicate that the Ang II-induced pressor response is a direct Ang II-mediated vascular response in elasmobranchs.
ISSN:	0920-1742 1573-5168
DOI:	10.1023/A:1007795200105