Vaccination of attenuated EIS-producing Salmonella induces protective immunity against enterohemorrhagic Escherichia coli in mice

Highlights ► Live attenuated Salmonella vaccine producing EspA–intiminC300–Stx2B (EIS) was constructed. ► Promising humoral and cellular responses to these antigens were observed in mice. ► Vaccination of EIS-producing Salmonella protects mice from lethal EHEC challenges. ► EIS-producing Salmonella...

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Veröffentlicht in:	Vaccine 2011-10, Vol.29 (43), p.7395-7403
Hauptverfasser:	Gu, Jiang, Ning, Yuanyuan, Wang, Haiguang, Xiao, Daping, Tang, Bin, Luo, Ping, Cheng, Yan, Jiang, Mingming, Li, Na, Zou, Quanming, Mao, Xuhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesins, Bacterial - immunology Allergy and Immunology Animals Antibiotics Antibodies, Bacterial - biosynthesis Antibodies, Bacterial - immunology Applied microbiology Attenuated Salmonella vaccine Bacteria Bacterial infections Bacteriology Biological and medical sciences Boost Cell Proliferation Cross Protection - immunology E coli Enterohemorrhagic Escherichia coli Enterohemorrhagic Escherichia coli - immunology Escherichia coli Escherichia coli Infections - immunology Escherichia coli Infections - prevention & control Escherichia coli Proteins - immunology Escherichia coli Vaccines - immunology Feces Fundamental and applied biological sciences. Psychology Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Infections Lymphocytes - immunology Mice Microbiology Miscellaneous Pathogenesis Plasmids Protective immunity Proteins Salmonella Salmonella - immunology Salmonella Vaccines - immunology Shiga Toxin 2 - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - immunology Vaccines, Synthetic - immunology
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Beschreibung
Zusammenfassung:	Highlights ► Live attenuated Salmonella vaccine producing EspA–intiminC300–Stx2B (EIS) was constructed. ► Promising humoral and cellular responses to these antigens were observed in mice. ► Vaccination of EIS-producing Salmonella protects mice from lethal EHEC challenges. ► EIS-producing Salmonella induced protective immunity can be boosted by injection of purified EIS protein.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.07.069