Melamine impairs spatial cognition and hippocampal synaptic plasticity by presynaptic inhibition of glutamatergic transmission in infant rats

Highlights ► An experimental melamine neurotoxic model of rats was establised. ► Behavior of rats in MWM test was impaired by melamine. ► In LTP test, the slope of fEPSP was altered in rats of melamine group. ► Melamine affected glutamatergic transmission in vitro experiment.

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Bibliographische Detailangaben
Veröffentlicht in:	Toxicology (Amsterdam) 2011-11, Vol.289 (2), p.167-174
Hauptverfasser:	Yang, Jiajia, An, Lei, Yao, Yang, Yang, Zhuo, Zhang, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences children cognition Cognition - drug effects Cognition - physiology electrophysiology Emergency Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology fetus glutamic acid Glutamic Acid - secretion Hippocampal CA1 neurons hippocampus Hippocampus - drug effects Hippocampus - secretion Long-term potential Male Medical sciences Melamine memory Neural Inhibition - drug effects Neural Inhibition - physiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology neurons patch-clamp technique Presynaptic Terminals - drug effects Presynaptic Terminals - secretion public health Random Allocation Rats Rats, Wistar Spatial Behavior - drug effects Spatial Behavior - physiology Spatial learning and memory Synapses - drug effects Synapses - secretion Synaptic transmission Synaptic Transmission - drug effects Synaptic Transmission - physiology toxicity Toxicology Triazines - toxicity
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Beschreibung
Zusammenfassung:	Highlights ► An experimental melamine neurotoxic model of rats was establised. ► Behavior of rats in MWM test was impaired by melamine. ► In LTP test, the slope of fEPSP was altered in rats of melamine group. ► Melamine affected glutamatergic transmission in vitro experiment.
ISSN:	0300-483X 1879-3185
DOI:	10.1016/j.tox.2011.08.011