Clinical Neisseria gonorrhoeae Isolates in the United States with Resistance to Azithromycin Possess Mutations in All 23S rRNA Alleles and the mtrR Coding Region

We identified strains of Neisseria gonorrhoeae in San Diego County, California, that possess high levels of resistance to azithromycin (8.0–16.0 μg/ml MIC). These isolates contain a combination of mutations in both the 23S rRNA loci and mtrR genes. This is the first description of such isolates in t...

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Veröffentlicht in:	Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2011-09, Vol.17 (3), p.425-427
Hauptverfasser:	Wu, Abel, Buono, Sean, Katz, Kenneth A., Pandori, Mark W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Substitution Anti-Bacterial Agents - pharmacology Antibiotics Azithromycin Azithromycin - pharmacology Bacteria Bacterial Proteins - genetics DNA, Bacterial - genetics DNA-Binding Proteins - genetics Drug resistance Drug resistance in microorganisms Drug Resistance, Bacterial Drug therapy Epidemiology Genetic aspects Health aspects Humans Microbial Sensitivity Tests - methods Mutation Neisseria gonorrhoeae Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Neisseria gonorrhoeae - isolation & purification Neisseria infections Operon - genetics Physiological aspects Promoter Regions, Genetic Repressor Proteins - genetics Ribosomal RNA RNA, Ribosomal, 23S - genetics Sequence Analysis, DNA - methods United States
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Zusammenfassung:	We identified strains of Neisseria gonorrhoeae in San Diego County, California, that possess high levels of resistance to azithromycin (8.0–16.0 μg/ml MIC). These isolates contain a combination of mutations in both the 23S rRNA loci and mtrR genes. This is the first description of such isolates in the United States.
ISSN:	1076-6294 1931-8448
DOI:	10.1089/mdr.2010.0199