Heart valve tissue engineering: quo vadis?

Heart valve tissue engineering: quo vadis?

Research highlights ► A living tissue engineered heart valve may accommodate somatic growth in young recipients. ► Native valve mechano-biological dynamics define design parameters of an engineered tissue valve. ► Valvular interstitial cells and extracellular matrix are the key elements of an engine...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current opinion in biotechnology 2011-10, Vol.22 (5), p.698-705
1. Verfasser: Schoen, Frederick J
Format: Artikel
Sprache:eng
Schlagworte:
Biotechnology
Criteria
Heart Valve Prosthesis - standards
Heart valves
Heart Valves - physiology
Humans
Internal Medicine
prostheses
Prosthetics
quality of life
Surgical implants
Survival
Tissue Engineering
Valves
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Research highlights ► A living tissue engineered heart valve may accommodate somatic growth in young recipients. ► Native valve mechano-biological dynamics define design parameters of an engineered tissue valve. ► Valvular interstitial cells and extracellular matrix are the key elements of an engineered valve. ► Heart valves are a particularly difficult application for realization of the tissue engineering approach. ► Key technical hurdles impose barriers to clinical implementation of engineered tissue heart valves.
ISSN:0958-1669
1879-0429
DOI:10.1016/j.copbio.2011.01.004