IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

Highlight ► IL-1R/TLR signaling activation by IL-1β, DAMPs or PAMPs decreases seizure threshold in epilepsy and can be targeted to attain anticonvulsant effects.

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Bibliographische Detailangaben
Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2011-10, Vol.25 (7), p.1281-1289
Hauptverfasser: Vezzani, Annamaria, Maroso, Mattia, Balosso, Silvia, Sanchez, Manuel-Alavez, Bartfai, Tamas
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Anticonvulsant
DAMPs
Epilepsy
Humans
Infection - immunology
Inflammation - immunology
Interleukins
LPS
Nerve Degeneration - immunology
Neurodegenerative Diseases - immunology
PAMPs
Psychiatry
Receptors, Interleukin-1 - metabolism
Seizures - immunology
Signal Transduction - physiology
Toll-Like Receptors - metabolism
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Beschreibung
Zusammenfassung:Highlight ► IL-1R/TLR signaling activation by IL-1β, DAMPs or PAMPs decreases seizure threshold in epilepsy and can be targeted to attain anticonvulsant effects.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.03.018