Time course of organ failure in patients with septic shock treated with hydrocortisone: results of the Corticus study

Introduction Corticosteroids have been proposed to decrease morbidity and mortality in patients with septic shock. An impact on morbidity should be anticipated to be earlier and more easily detected than the impact on mortality. Methods Prospective, randomized, double-blind, placebo-controlled study...

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Veröffentlicht in:	Intensive care medicine 2011-11, Vol.37 (11), p.1765-1772, Article 1765
Hauptverfasser:	Moreno, R., Sprung, C. L., Annane, D., Chevret, S., Briegel, J., Keh, D., Singer, M., Weiss, Y. G., Payen, D., Cuthbertson, B. H., Vincent, J.-L.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthesiology Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Care and treatment Critical care Critical Care Medicine Double-Blind Method Emergency and intensive care: infection, septic shock Emergency Medicine Europe - epidemiology Germany Health aspects Hospital Mortality Hospitals Humans Hydrocortisone Hydrocortisone - administration & dosage Hydrocortisone - therapeutic use Infections Intensive Intensive care Intensive care medicine Intensive Care Units Liver diseases Medical sciences Medicine Medicine & Public Health Middle Aged Morbidity Mortality Multiple Organ Failure - etiology Multiple Organ Failure - mortality Multiple Organ Failure - prevention & control Original Outcome Assessment (Health Care) Pain Medicine Pediatrics Pneumology/Respiratory System Prospective Studies Sepsis Septic shock Shock, Septic - complications Shock, Septic - drug therapy Shock, Septic - mortality Steroids Time Factors Vital signs Young Adult
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Zusammenfassung:	Introduction Corticosteroids have been proposed to decrease morbidity and mortality in patients with septic shock. An impact on morbidity should be anticipated to be earlier and more easily detected than the impact on mortality. Methods Prospective, randomized, double-blind, placebo-controlled study of 28-day mortality in patients with septic shock for
ISSN:	0342-4642 1432-1238
DOI:	10.1007/s00134-011-2334-x