Mutations in BHD and TP53 genes, but not in HNF1b gene, in a large series of sporadic chromophobe renal cell carcinoma

Mutations in BHD and TP53 genes, but not in HNF1b gene, in a large series of sporadic chromophobe renal cell carcinoma

BHD, TP53, and HNF1b on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1b mutations, (84% mutations involved chromophobe), suggesting a role for BHD a...

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Veröffentlicht in:British journal of cancer 2007-01, Vol.96 (2), p.336-340
Hauptverfasser: Gad, S, Lefevre, S H, Khoo, S K, Giraud, S, Vieillefond, A, Vasiliu, V, Ferlicot, S, Molinie, V, Denoux, Y, Thiounn, N, Chretien, Y, Mejean, A, Zerbib, M, Benoit, G, Herve, J M, Allegre, G, Bressac-de Paillerets, B, Teh, B T, Richard, S
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Sprache:eng
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Zusammenfassung:BHD, TP53, and HNF1b on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1b mutations, (84% mutations involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.British Journal of Cancer (2007) 96, 336-340. doi:10.1038/sj.bjc.6603492 www.bjcancer.com Published online 28 November 2006
ISSN:0007-0920
DOI:10.1038/sj.bjc.6603492