Targeting tuberculosis through a small focused library of 1,2,3-triazoles

Looking for new active molecules against Mycobacterium tuberculosis , a small focused library of 1,2,3-triazoles was efficiently prepared by click chemistry. Compounds were subsequently tested against different pathogenic and opportunistic mycobacteria including M. avium and M. tuberculosis . Two of them showed MIC at lower μg/mL concentration for M. avium and even below that for M. tuberculosis , being more potent that control drugs.