Anti-diabetic activity of a mineraloid isolate, in vitro and in genetically diabetic mice
Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial...
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| Veröffentlicht in: | International journal for vitamin and nutrition research 2011-01, Vol.81 (1), p.34-42 |
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| container_title | International journal for vitamin and nutrition research |
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| creator | Deneau, Joel Ahmed, Taufeeq Blotsky, Roger Bojanowski, Krzysztof |
| description | Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models. |
| doi_str_mv | 10.1024/0300-9831/a000048 |
| format | Article |
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| subjects | Animals Cells, Cultured Coal Mining - economics Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diet therapy Dietary Supplements Gene Expression Profiling Glycated Hemoglobin A - analysis Glycation End Products, Advanced - analysis Humans Hyperglycemia - prevention & control Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - metabolism Hypoglycemic Agents - therapeutic use Industrial Waste - analysis Industrial Waste - economics Mice Mice, Inbred NOD Minerals - administration & dosage Minerals - metabolism Minerals - therapeutic use Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Oligonucleotide Array Sequence Analysis RNA Precursors - metabolism RNA, Messenger - metabolism Skin - cytology Skin - metabolism Up-Regulation Weight Gain |
| title | Anti-diabetic activity of a mineraloid isolate, in vitro and in genetically diabetic mice |
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