8q24.3 and 11q25 chromosomal loci association with low HDL-C in metabolic syndrome

Eur J Clin Invest 2011; 41 (10): 1105–1112 Background High‐density lipoprotein cholesterol (HDL‐C) levels are low in Iranians. Low HDL‐C is the most frequent phenotype in metabolic syndrome (MetS) among the Iranian population (32%). This has been claimed to be related to genetic factors. Materials and methods To investigate possible genes linked to this disorder, 12 microsatellite markers were selected. They were used in 107 families with MetS and low HDL‐C to analyse relevant association and linkage signals. Result Family‐based association tests under the biallelic mode gave many positive association signals. Higher association – after correction for multiple testing – was found to be linked with marker D8S1743 and D11S1304 (P