Differentiating Inherited Human Herpesvirus Type 6 Genome from Primary Human Herpesvirus Type 6 Infection by Means of Dried Blood Spot from the Newborn Screening Card
To differentiate active human herpesvirus type 6 (HHV-6) infection from inherited HHV-6 (iHHV-6), we analyzed dried blood spots from archived newborn screening cards in 3 patients with high HHV-6 DNA copy numbers. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. In 1 patient,...
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| Veröffentlicht in: | The Journal of pediatrics 2011-11, Vol.159 (5), p.859-861 |
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| container_title | The Journal of pediatrics |
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| creator | Strenger, Volker, MD Pfurtscheller, Klaus, MD Wendelin, Gerald, MD Aberle, Stephan W., MD Nacheva, Elisabeth P., MD, PhD Zöhrer, Bettina, MD Zenz, Werner, MD Nagel, Bert, MD Zobel, Gerfried, MD Popow-Kraupp, Therese, MD |
| description | To differentiate active human herpesvirus type 6 (HHV-6) infection from inherited HHV-6 (iHHV-6), we analyzed dried blood spots from archived newborn screening cards in 3 patients with high HHV-6 DNA copy numbers. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. In 1 patient, the absence of HHV-6 DNA excluded iHHV-6. |
| doi_str_mv | 10.1016/j.jpeds.2011.06.032 |
| format | Article |
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Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. In 1 patient, the absence of HHV-6 DNA excluded iHHV-6.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2011.06.032</identifier><identifier>PMID: 21840541</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>Maryland Heights, MO: Elsevier Inc</publisher><subject>Biological and medical sciences ; blood ; Child ; Child, Preschool ; DNA ; DNA, Viral - analysis ; Dried Blood Spot Testing ; Female ; General aspects ; genome ; Genome, Viral ; Herpesviridae Infections - congenital ; Herpesviridae Infections - diagnosis ; Herpesvirus 6, Human - genetics ; Human herpesvirus 6 ; Humans ; In Situ Hybridization, Fluorescence ; Infant, Newborn ; inheritance (genetics) ; Male ; Medical sciences ; Neonatal Screening ; neonates ; patients ; Pediatrics ; Polymerase Chain Reaction ; Prevention and actions ; Public health. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-cd4b9f8451935ea54d8123e755a7ee7cdd378092931a21a5e3a0880662c343c3</citedby><cites>FETCH-LOGICAL-c467t-cd4b9f8451935ea54d8123e755a7ee7cdd378092931a21a5e3a0880662c343c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2011.06.032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24719739$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21840541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strenger, Volker, MD</creatorcontrib><creatorcontrib>Pfurtscheller, Klaus, MD</creatorcontrib><creatorcontrib>Wendelin, Gerald, MD</creatorcontrib><creatorcontrib>Aberle, Stephan W., MD</creatorcontrib><creatorcontrib>Nacheva, Elisabeth P., MD, PhD</creatorcontrib><creatorcontrib>Zöhrer, Bettina, MD</creatorcontrib><creatorcontrib>Zenz, Werner, MD</creatorcontrib><creatorcontrib>Nagel, Bert, MD</creatorcontrib><creatorcontrib>Zobel, Gerfried, MD</creatorcontrib><creatorcontrib>Popow-Kraupp, Therese, MD</creatorcontrib><title>Differentiating Inherited Human Herpesvirus Type 6 Genome from Primary Human Herpesvirus Type 6 Infection by Means of Dried Blood Spot from the Newborn Screening Card</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To differentiate active human herpesvirus type 6 (HHV-6) infection from inherited HHV-6 (iHHV-6), we analyzed dried blood spots from archived newborn screening cards in 3 patients with high HHV-6 DNA copy numbers. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. In 1 patient, the absence of HHV-6 DNA excluded iHHV-6.</description><subject>Biological and medical sciences</subject><subject>blood</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>DNA</subject><subject>DNA, Viral - analysis</subject><subject>Dried Blood Spot Testing</subject><subject>Female</subject><subject>General aspects</subject><subject>genome</subject><subject>Genome, Viral</subject><subject>Herpesviridae Infections - congenital</subject><subject>Herpesviridae Infections - diagnosis</subject><subject>Herpesvirus 6, Human - genetics</subject><subject>Human herpesvirus 6</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Infant, Newborn</subject><subject>inheritance (genetics)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neonatal Screening</subject><subject>neonates</subject><subject>patients</subject><subject>Pediatrics</subject><subject>Polymerase Chain Reaction</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>screening</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks-O0zAQhyMEYsvCEyCBL4hTy9hO7OQAEnRhW2n5I7WcLdeZ7LokdrCTRX0hnhOXFJCQEKe5fDPz03yTZY8pLChQ8WK_2PdYxwUDShcgFsDZnWxGoZJzUXJ-N5sBMDbnuRRn2YMY9wBQ5QD3szNGyxyKnM6y7xe2aTCgG6werLsma3eDwQ5Yk9XYaUdWGHqMtzaMkWwPPRJBLtH5DkkTfEc-BdvpcPg3vHYNmsF6R3YH8h61i8Q35CLYtOFN631NNr0fpmHDDZIP-G3ngyMbExDdMdFSh_phdq_RbcRHp3qebd-93S5X86uPl-vl66u5yYUc5qbOd1VT5gWteIG6yOuSMo6yKLRElKauuSyhYhWnmlFdINdQliAEMzznhp9nz6exffBfR4yD6mw02LbaoR-jKquyACmYSCSfSBN8jAEb1U-XUBTUUY_aq5961FGPAqGSntT15DR_3HVY_-755SMBz06Ajka3TdDO2PiHyyWtJK8S93TiGu2Vvg6J-bxJm4rkuJRcyES8nAhM57q1GFQ0Fp3B2oYkRNXe_ifqq7_6TWudTaG-4AHj3o_BJROKqsgUqM3x146vRimAKFLIH1Fazbg</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Strenger, Volker, MD</creator><creator>Pfurtscheller, Klaus, MD</creator><creator>Wendelin, Gerald, MD</creator><creator>Aberle, Stephan W., MD</creator><creator>Nacheva, Elisabeth P., MD, PhD</creator><creator>Zöhrer, Bettina, MD</creator><creator>Zenz, Werner, MD</creator><creator>Nagel, Bert, MD</creator><creator>Zobel, Gerfried, MD</creator><creator>Popow-Kraupp, Therese, MD</creator><general>Elsevier Inc</general><general>Mosby, Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Differentiating Inherited Human Herpesvirus Type 6 Genome from Primary Human Herpesvirus Type 6 Infection by Means of Dried Blood Spot from the Newborn Screening Card</title><author>Strenger, Volker, MD ; Pfurtscheller, Klaus, MD ; Wendelin, Gerald, MD ; Aberle, Stephan W., MD ; Nacheva, Elisabeth P., MD, PhD ; Zöhrer, Bettina, MD ; Zenz, Werner, MD ; Nagel, Bert, MD ; Zobel, Gerfried, MD ; Popow-Kraupp, Therese, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-cd4b9f8451935ea54d8123e755a7ee7cdd378092931a21a5e3a0880662c343c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>blood</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>DNA</topic><topic>DNA, Viral - analysis</topic><topic>Dried Blood Spot Testing</topic><topic>Female</topic><topic>General aspects</topic><topic>genome</topic><topic>Genome, Viral</topic><topic>Herpesviridae Infections - congenital</topic><topic>Herpesviridae Infections - diagnosis</topic><topic>Herpesvirus 6, Human - genetics</topic><topic>Human herpesvirus 6</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Infant, Newborn</topic><topic>inheritance (genetics)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neonatal Screening</topic><topic>neonates</topic><topic>patients</topic><topic>Pediatrics</topic><topic>Polymerase Chain Reaction</topic><topic>Prevention and actions</topic><topic>Public health. 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| subjects | Biological and medical sciences blood Child Child, Preschool DNA DNA, Viral - analysis Dried Blood Spot Testing Female General aspects genome Genome, Viral Herpesviridae Infections - congenital Herpesviridae Infections - diagnosis Herpesvirus 6, Human - genetics Human herpesvirus 6 Humans In Situ Hybridization, Fluorescence Infant, Newborn inheritance (genetics) Male Medical sciences Neonatal Screening neonates patients Pediatrics Polymerase Chain Reaction Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine screening |
| title | Differentiating Inherited Human Herpesvirus Type 6 Genome from Primary Human Herpesvirus Type 6 Infection by Means of Dried Blood Spot from the Newborn Screening Card |
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