Differentiating Inherited Human Herpesvirus Type 6 Genome from Primary Human Herpesvirus Type 6 Infection by Means of Dried Blood Spot from the Newborn Screening Card

To differentiate active human herpesvirus type 6 (HHV-6) infection from inherited HHV-6 (iHHV-6), we analyzed dried blood spots from archived newborn screening cards in 3 patients with high HHV-6 DNA copy numbers. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. In 1 patient,...

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Veröffentlicht in:	The Journal of pediatrics 2011-11, Vol.159 (5), p.859-861
Hauptverfasser:	Strenger, Volker, MD, Pfurtscheller, Klaus, MD, Wendelin, Gerald, MD, Aberle, Stephan W., MD, Nacheva, Elisabeth P., MD, PhD, Zöhrer, Bettina, MD, Zenz, Werner, MD, Nagel, Bert, MD, Zobel, Gerfried, MD, Popow-Kraupp, Therese, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences blood Child Child, Preschool DNA DNA, Viral - analysis Dried Blood Spot Testing Female General aspects genome Genome, Viral Herpesviridae Infections - congenital Herpesviridae Infections - diagnosis Herpesvirus 6, Human - genetics Human herpesvirus 6 Humans In Situ Hybridization, Fluorescence Infant, Newborn inheritance (genetics) Male Medical sciences Neonatal Screening neonates patients Pediatrics Polymerase Chain Reaction Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine screening
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Zusammenfassung:	To differentiate active human herpesvirus type 6 (HHV-6) infection from inherited HHV-6 (iHHV-6), we analyzed dried blood spots from archived newborn screening cards in 3 patients with high HHV-6 DNA copy numbers. Two patients were positive for HHV-6 DNA as neonates suggesting iHHV-6. In 1 patient, the absence of HHV-6 DNA excluded iHHV-6.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2011.06.032