Palladium Catalyzed Stereoselective C-Glycosylation of Glycals with Enol Triflates

Palladium Catalyzed Stereoselective C-Glycosylation of Glycals with Enol Triflates

An efficient palladium catalyzed C-glycosylation of glycals with enol triflates has been established. The coupling reactions took place on the anomeric carbon, and the coupling products gave exclusively α isomers. The flexibility of the reaction was exemplified by the broad spectra of substrate scop...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2011-10, Vol.13 (20), p.5648-5651
Hauptverfasser: Bai, Yaguang, Leow, Minli, Zeng, Jing, Liu, Xue-Wei
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrates - chemistry
Catalysis
Combinatorial Chemistry Techniques
Glycosides - chemistry
Glycosylation
Mesylates - chemistry
Palladium - chemistry
Stereoisomerism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An efficient palladium catalyzed C-glycosylation of glycals with enol triflates has been established. The coupling reactions took place on the anomeric carbon, and the coupling products gave exclusively α isomers. The flexibility of the reaction was exemplified by the broad spectra of substrate scope, constituted of glycals protected with good leaving groups as well as an assortment of enol triflates.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202368n