Development of a mathematical model for evaluating the dynamics of normal and apoptotic Chinese hamster ovary cells

A metabolic flux based methodology was developed for modeling the metabolism of a Chinese hamster ovary cell line. The elimination of insignificant fluxes resulted in a simplified metabolic network which was the basis for modeling the significant metabolites. Employing kinetic rate expressions for g...

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Veröffentlicht in:	Biotechnology progress 2011-09, Vol.27 (5), p.1197-1205
Hauptverfasser:	Naderi, Saeideh, Meshram, Mukesh, Wei, Catherine, McConkey, Brendan, Ingalls, Brian, Budman, Hector, Scharer, Jeno
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies, Monoclonal - biosynthesis Apoptosis Batch culture Biological and medical sciences Biotechnology Cell culture CHO CHO Cells Cricetinae Cricetulus Data processing Fundamental and applied biological sciences. Psychology Kinetics logistic equation mathematical modeling Mathematical models metabolic flux metabolic flux analysis metabolic networks Metabolites Models, Theoretical Monoclonal antibodies Nutrient concentrations Secretion
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