Prognostic Impact of Standardized Uptake Value of F-18 FDG PET/CT in Nasopharyngeal Carcinoma

Prognostic Impact of Standardized Uptake Value of F-18 FDG PET/CT in Nasopharyngeal Carcinoma

PURPOSE:We evaluated the use of metabolic parameters of F-18 fluorodeoxyglucose positron emission tomography (FDG PET) for the assessment of the primary tumor and nodal metastasis in predicting survival in nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS:The F-18 FDG PET/CT (computed t...

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Veröffentlicht in:Clinical nuclear medicine 2011-11, Vol.36 (11), p.1007-1011
Hauptverfasser: Chan, Winnie K. S, Kwong, Dora Lai-Wan, Yeung, David W. C, Huang, Bingsheng, Khong, Pek-Lan
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Carcinoma
Disease-Free Survival
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Male
Middle Aged
Multimodal Imaging
Multivariate Analysis
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - diagnostic imaging
Positron-Emission Tomography
Prognosis
Proportional Hazards Models
Reference Standards
Tomography, X-Ray Computed
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Zusammenfassung:PURPOSE:We evaluated the use of metabolic parameters of F-18 fluorodeoxyglucose positron emission tomography (FDG PET) for the assessment of the primary tumor and nodal metastasis in predicting survival in nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS:The F-18 FDG PET/CT (computed tomography) scans of 46 consecutive newly diagnosed NPC patients were retrospectively reviewed. Maximal standardized uptake value (SUVmax) corrected for lean body mass of primary tumor (pSUVmax) and highest SUVmax of cervical lymph nodes (nSUVmax) were recorded. The association of FDG uptake and 2-year disease-free survival (DFS) was examined. RESULTS:Significantly better DFS was found in patients with pSUVmax
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0b013e31821a29a4